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學術論文

匯集病理基礎模型、影像分析與臨床應用的研究成果。

研究成果發表於:Nature Machine Intelligence · IEEE TMI · NeurIPS · CVPR · ICLR

精選團隊論文及相關臨床文獻。

精選研究

重點論文

團隊及合作研究者發表的同行評審論文。

D-PathAI相關臨床研究

選讀乳腺癌領域已通過同行評審的臨床研究,了解D-PathAI在研究中的用途、主要結果及局限。

期刊論文 西湖大學共同署名

HER2-LADDER:HER2 陽性乳腺癌治療反應預測研究

Wu et al. · Signal Transduction and Targeted Therapy 11, 241 (2026)

發表於 2026 年 6 月 19 日

研究結合治療前活檢的H&E、HER2 IHC切片及臨床資料,建立研究用評分,預測患者接受新輔助雙靶向抗HER2治療後能否達到病理完全緩解。

研究設計 & 研究局限
研究設計
研究以復旦大學附屬腫瘤醫院276例病例建立模型,再以三個隊列驗證:時序驗證隊列82例、來自臨床試驗的驗證隊列85例,以及重慶外部驗證隊列40例。
D-PathAI 的作用
研究採用定製的D-PathAI分析流程,測量腫瘤細胞HER2膜染色的強度及完整性;H&E影像由HoVer-Net分析,再由研究團隊建立的模型整合相關特徵。
研究局限
回顧性分析可能存在選擇偏倚。作者指出,在更廣泛的臨床應用前,仍須進行前瞻性驗證,並統一染色及掃描流程。
期刊論文 外部臨床研究

HER2判讀一致性:研究結果及局限

Dong et al. · npj Breast Cancer 12, 9 (2026)

首次發表於 2025 年 12 月 9 日;正式版本日期為 2026 年 1 月 12 日

研究使用HER2 IHC切片及判讀評分,評估染色結果的可重複性、不同閱片者評分的一致性,以及閱片者評分與共識評分的符合程度。

研究設計 & 研究局限
研究設計
研究對中國醫科大學附屬第一醫院的1,455例病例進行回顧性分析,並評估45家實驗室的染色情況;另選209張切片,比較人工判讀與AI輔助判讀。
D-PathAI 的作用
在209張切片的比較中,D-PathAI用於輔助HER2 IHC判讀。該組數據顯示,AI輔助判讀的一致性較高。
研究局限
研究仍發現細胞檢測錯誤及非特異性染色干擾,亦未能可靠區分HER2超低表達與零表達,結果仍須人工核實。

上述結果是在論文所述的研究條件下取得,不能直接代表所有現售模組、掃描儀及部署方式的性能。實際應用仍須按具體產品配置及預期用途另行評估。

論文庫

按研究主題瀏覽,或搜尋論文標題、作者、期刊與會議。

基礎模型

研究大規模病理基礎模型對影像區塊、全切片影像及病理報告的理解能力,涵蓋多模態及生成式方法。

NeurIPS

CPathAgent: An Agent-based Foundation Model for Interpretable High-Resolution Pathology Image Analysis Mimicking Pathologists' Diagnostic Logic

會議論文 西湖大學共同署名

Sun, Y., Si, Y., Zhu, C., Zhang, K., Shui, Z., Ding, B., Lin, T., Yang, L. · NeurIPS 2025 · 2025

NeurIPS

PathVQ: Reforming Computational Pathology Foundation Model for Whole Slide Image Analysis via Vector Quantization

會議論文 西湖大學共同署名

Li, H., Shui, Z., Zhang, Y., Zhu, C., Yang, L. · NeurIPS 2025 · 2025

TMI

ToPoFM: Topology-Guided Pathology Foundation Model for High-Resolution Pathology Image Synthesis with Cellular-Level Control

Li, J., Zhu, C., Zheng, S., Chen, P., Sun, Y., Li, H., Yang, L. · IEEE Trans. Medical Imaging · 2025

CVPR

CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathology

Sun, Y., Si, Y., Zhu, C., Gong, X., Zhang, K., Chen, P., Zhang, Y., Shui, Z., Lin, T., Yang, L. · CVPR 2025 (CCF-A) · 2025

ICLR

PathGen-1.6M: 1.6 Million Pathology Image-text Pairs Generation through Multi-agent Collaboration

Sun, Y., Zhang, Y., Si, Y., Zhu, C., Zhang, K., Shui, Z., Li, J., Gong, X., Lyu, X., Lin, T., Yang, L. · ICLR 2025 (Oral) · 2025

AAAI

PathAsst: A Generative Foundation AI Assistant towards Artificial General Intelligence of Pathology

Sun, Y., Zhu, C., Zheng, S., Zhang, K., Sun, L., Shui, Z., Zhang, Y., Li, H., Yang, L. · AAAI 2024 (CCF-A, Oral) · 2024

ECCV

WSI-VQA: Interpreting Whole Slide Images by Generative Visual Question Answering

Chen, P., Zhu, C., Zheng, S., Li, H., Yang, L. · ECCV 2024 (CCF-A) · 2024

ACM MM

PathUp: Patch-wise Timestep Tracking for Multi-class Large Pathology Image Synthesising Diffusion Model

Li, J., Zheng, S., Zhu, C., Sun, Y., Chen, P., Shui, Z., Zhang, Y., Li, H., Yang, L. · ACM MM 2024 (CCF-A, Oral) · 2024

MICCAI

WSICaption: Multiple Instance Generation of Pathology Reports for Gigapixel Whole-Slide Images

Chen, P., Li, H., Zhu, C., Zheng, S., Shui, Z., Yang, L. · MICCAI 2024 (CCF-B, Oral) · 2024

應用研究

收錄針對具體病理任務的方法研究、團隊合作成果及外部臨床文獻。

STTT

Spatially interpretable artificial intelligence framework to tailored neoadjuvant dual HER2 blockade in HER2-positive breast cancer

期刊論文 西湖大學共同署名 臨床研究 HER2 D-PathAI 新輔助治療

Wu, X.-R., Lv, H., Zhao, S., Zeng, X.-H., Dai, L.-J., Xu, Y.-Z., Li, Y.-W., Qiu, Z.-Y., Huang, J.-T., Zhang, N.-N., Chen, L., He, M., Zhao, Y.-Z., Yang, L., Zhou, T., Li, J.-J., Wu, J., Jiang, Y.-Z., Yang, W.-T., Di, G.-H., Shao, Z.-M., Ma, D. · Signal Transduction and Targeted Therapy · 2026

npj Breast

HER2-low and ultralow expression of invasive breast carcinoma: clinicopathological features and immunohistochemical consistency analysis

期刊論文 外部臨床研究 使用D-PathAI 臨床研究 HER2 IHC AI輔助評分

Dong, Y.-h., Xu, Y.-t., Jiang, X.-z., Xu, L., Yu, R.-j., Wang, R., Zhang, Q.-f. · npj Breast Cancer · 2026

USCAP

Differentiation Between HER2 Ultra-Low and HER2 Null Breast Cancers Using an AI Support Tool: A Multi-Site Study

會議摘要 外部臨床參考 臨床研究 HER2 超低表達 IHC 多中心研究

Grinwald, M., Schnitt, S., Vincent-Salomon, A., et al. · USCAP 2025 · Abstract 156 · 2025

USCAP

Artificial Intelligence Assisted Assessment of HER2-ultralow and HER2-low Immunohistochemical Scoring in Breast Cancer Core Needle Biopsy Specimens

會議摘要 外部臨床參考 臨床研究 HER2 IHC 粗針穿刺活檢

Li, M., Cai, M., Lv, H., Zhou, S., Lin, M., Shui, R., Yang, W. · USCAP 2024 · Abstract 178 · 2024

SABCS

The Advantage of Artificial-Intelligence in HER2 IHC 0 and 1+ Scoring in Breast Cancer

壁報摘要 西湖大學共同署名 臨床研究 HER2 IHC AI評分

Li, M., Lv, H., Zhao, Y., Zhu, C., Li, H., Lin, M., Yang, W. · SABCS 2023 · Cancer Research 84(9 Suppl.), PO4-26-09 · 2024

AAAI

Towards Effective and Efficient Context-aware Nucleus Detection in Histopathology Whole Slide Images

會議論文 西湖大學共同署名

Shui, Z., Li, H., Zhang, Y., Sun, Y., Ye, Y., Chen, P., Guo, R., Cui, L., Zhu, C., Yang, L. · AAAI 2026 · 2026

PLOS One

Weakly supervised deep multi-instance learning for classification of endometrial lesions on hematoxylin and eosin-stained whole-slide images

期刊論文 西湖大學共同署名

Zhou, Z., Guo, J., Du, X., Li, H., Xie, N., Liu, C., He, H., Yang, L., Cui, L., Fu, C. · PLOS One · 2026

MICCAI

AEM: Attention Entropy Maximization for Multiple Instance Learning based Whole Slide Image Classification

會議論文 西湖大學共同署名

Zhang, Y., Li, H., Sun, Y., Shui, Z., Li, J., Zhu, C., Yang, L. · MICCAI 2025 · 2025

Allergy

Artificial Intelligence-Based Pathological Subtype Diagnosis of Nasal Polyps: A Multidimensional and Micro-Visualization Study

臨床研究 鼻息肉

Luo, X., Li, H., Chen, J., Zhou, Z., Zhou, L., Luo, R., ..., Cui, L., Yang, L., Yang, Q. · Allergy · 2026

ICASSP

Stable Test-Time Training for Semantic Segmentation with Output Contrastive Loss

Zhang, Y., Shui, Z., Li, H., Sun, Y., Zhu, C., Yang, L. · ICASSP 2025 (CCF-B) · 2025

Cancer Cell

Spatial determinants of antibody-drug conjugate SHR-A1811 efficacy in neoadjuvant treatment for HER2-positive breast cancer

臨床研究 HER2 新輔助治療

Ma, D., Dai, L.-J., Wu, X.-R., Liu, C.-L., Zhao, S., Zhang, H., Chen, L., Xiao, Y., Li, M., Zhao, Y.-Z., ... · Cancer Cell · 2025

ECCV

Attention-Challenging Multiple Instance Learning for Whole Slide Image Classification

Zhang, Y., Li, H., Sun, Y., Zheng, S., Zhu, C., Yang, L. · ECCV 2024 (CCF-A) · 2024

ECCV

Unleashing the Power of Prompt-Driven Nucleus Instance Segmentation

Shui, Z., Zhang, Y., Yao, K., Zhu, C., Zheng, S., Li, J., Li, H., Sun, Y., Guo, R., Yang, L. · ECCV 2024 (CCF-A) · 2024

NeurIPS

Rethinking Transformer for Long Contextual Histopathology Whole Slide Image Analysis

Li, H., Zhang, Y., Chen, P., Shui, Z., Zhu, C., Yang, L. · NeurIPS 2024 (CCF-A) · 2024

AAAI

DPA-P2PNet: Deformable Proposal-Aware P2PNet for Accurate Point-Based Cell Detection

Shui, Z., Zheng, S., Zhu, C., Zhang, S., Yu, X., Li, H., Li, J., Chen, P., Yang, L. · AAAI 2024 (CCF-A) · 2024

Neural Net.

Gradient-Aware Learning for Joint Biases: Label Noise and Class Imbalance

Zhang, S., Zhu, C., Li, H., Cai, J., Yang, L. · Neural Networks · 2024

CSBJ

Performance of a HER2 Testing Algorithm Tailored for Urothelial Bladder Cancer: A Bi-centre Study

臨床研究 HER2 IHC

Huang, A., Zhao, Y., Guan, F., Zhang, H., ... · Computational and Structural Biotechnology Journal · 2024

ICME

Context-Aware Text-Assisted Multimodal Framework for Cervical Cytology Cell Diagnosis and Chatting

臨床研究 TCT 子宮頸細胞學

Sun, Y., Zhu, C., Zheng, S., Zhang, Y., Li, H., Yang, L. · ICME 2024 (CCF-B) · 2024

ICASSP

HLS-FGVC: Hierarchical Label Semantics Enhanced Fine-Grained Visual Classification

Zhang, S., Zheng, S., Shui, Z., Yang, L. · ICASSP 2024 (CCF-B) · 2024

BIBM

Multi-modal Learning with Missing Modality in Predicting Axillary Lymph Node Metastasis

Zhang, S., Zheng, S., Shui, Z., Li, H., Yang, L. · BIBM 2023 (CCF-B) · 2023

CVPR

Task-specific Fine-tuning via Variational Information Bottleneck for Weakly-supervised Pathology WSI Classification

Li, H., Zhu, C., Zhang, Y., Sun, Y., Shui, Z., Kuang, W., Zheng, S., Yang, L. · CVPR 2023 (CCF-A) · 2023

MICCAI

Segment Membranes and Nuclei from Histopathological Images via Nuclei Point-Level Supervision

臨床研究 IHC 細胞膜分割

Li, H., Xu, Z., Zhou, M., Shi, X., Kang, Y., Bu, Q., Lv, H., Li, M., Lin, M., Cui, L., Feng, J., Yang, W., Yang, L. · MICCAI 2023 (CCF-B) · 2023

TMI

Masked Conditional Variational Autoencoders for Chromosome Straightening

Li, J., Zheng, S., Shui, Z., Zhang, S., Yang, L., Sun, Y., Zhang, Y., Li, H., ... · IEEE Trans. Medical Imaging · 2023

MICCAI

Exploring Unsupervised Cell Recognition with Prior Self-Activation Maps

Chen, P., Zhu, C., Shui, Z., Cai, J., Zheng, S., Zhang, S., Yang, L. · MICCAI 2023 (CCF-B) · 2023

MICCAI

End-to-End Cell Recognition by Point Annotation

Shui, Z., Zhang, S., Zhu, C., Wang, B., Chen, P., Zheng, S., Yang, L. · MICCAI 2022 (CCF-B) · 2022

MICCAI

ChrsNet: Chromosome Straightening Using Self-Attention Guided Networks

Zheng, S., Li, J., Shui, Z., Zhu, C., Zhang, Y., Chen, P., Yang, L. · MICCAI 2022 (CCF-B) · 2022

ISBI

Weakly Supervised Learning for Cell Recognition in Immunohistochemical Cytoplasm Staining Images

臨床研究 IHC

Zhang, S., Zhu, C., Li, H., Cai, J., Yang, L. · ISBI 2022 · 2022

ISBI

Category Separation For Weakly Supervised Multi-Class Cell Counting

Cai, J., Zhu, C., Chen, P., Zhang, S., Li, H., Sun, Y., Yang, L. · ISBI 2022 · 2022

ISBI

Weakly Supervised Classification Using Multi-Level Instance-Aware Optimization on Cervical Cytologic Image

臨床研究 TCT

Zhu, C., Sun, Y., Li, H., Cui, C., Zhang, S., Cai, J., Ling, Y. · ISBI 2022 · 2022

MICCAI

Generalizing Nucleus Recognition Model in Multi-Source Ki67 Immunohistochemistry Stained Images via Domain-Specific Pruning

臨床研究 IHC Ki67

Cai, J., Zhu, C., Cui, C., Li, H., Wu, T., Zhang, S., Yang, L. · MICCAI 2021 (CCF-B) · 2021

J. Transl. Med.

Automated Tumor Proportion Scoring for PD-L1 Expression Based on Multistage Ensemble Strategy in NSCLC

臨床研究 PD-L1 IHC

Pan, B., Kang, Y., Jin, Y., Yang, L., Zheng, Y., Cui, L., Sun, J., Feng, J., Li, Y., Guo, L., Liang, Z. · J. Translational Medicine · 2021

AI Med.

Rule-based automatic diagnosis of thyroid nodules from intraoperative frozen sections using deep learning

臨床研究 冰凍切片 甲狀腺

Li, Y., Chen, P., Li, Z., Su, H., Yang, L., Zhong, D. · Artificial Intelligence in Medicine · 2020

Nature Mach. Intell.

Pathologist-level Interpretable Whole-slide Cancer Diagnosis with Deep Learning

Zhang, Z., Chen, P., McGough, M., ..., Cui, L., ..., Yang, L. · Nature Machine Intelligence · 2019

基準測試

評測病理AI在影像區塊及全切片分析中的表現,研究模型的穩健性。

TMI

PathBench: Advancing the Benchmark of Large Multimodal Models for Pathology Image Understanding at Patch and Whole Slide Level

Sun, Y., Wu, H., Zhu, C., Si, Y., Chen, Q., Zhang, Y., Zhang, K., Li, J., Cai, J., Wang, Y., ... · IEEE Trans. Medical Imaging · 2025

ECCV

PathMMU: A Massive Multimodal Expert-Level Benchmark for Understanding and Reasoning in Pathology

Sun, Y., Wu, H., Zhu, C., Zheng, S., Chen, Q., Zhang, K., Zhang, Y., Wan, D., Lan, X., ... · ECCV 2024 (CCF-A, Oral) · 2024

JIIM

Benchmarking PathCLIP for Pathology Image Analysis

Zheng, S., Cui, X., Sun, Y., Li, J., Li, H., Zhang, Y., Chen, P., Jing, X., Ye, Z., Yang, L. · J. Imaging Informatics in Medicine · 2024

ICASSP

Assessing the Robustness of Deep Learning-Assisted Pathological Image Analysis Under Practical Variables of Imaging System

Sun, Y., Zhu, C., Zhang, Y., Li, H., Chen, P., Yang, L. · ICASSP 2023 (CCF-B) · 2023

MICCAI

Benchmarking the Robustness of Deep Neural Networks to Common Corruptions in Digital Pathology

Zhang, Y., Sun, Y., Li, H., Zheng, S., Zhu, C., Yang, L. · MICCAI 2022 (CCF-B) · 2022

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